Nuclear Receptors: From Structure to the Clinic Paperback – Import 28 Oct 2016
Product Description Review Given the rapid advances in the field of nuclear receptor research especially their role in cell proliferation metabolism and homeostasis which make them prime targets for a wide range of diseases such as cancer and metabolic diseases this book does an excellent job of covering their structure and function and translational opportunities for drug discovery. The book targets students scientists and other clinicians such as oncologists and endocrinologists interested in the field of nuclear receptors. (Omer Iqbal Doody s Book Reviews October 2015)" From the Back Cover "Nuclear Receptors" focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together for the first time a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone drugs DNA response elements protein-protein interactions) and receptor activity. The nuclear receptor superfamily including receptors for steroid hormones and non-steroid ligands are pivotal to normal physiology regulating processes as diverse as reproduction metabolism the immune system and brain development. The first members of the family were cloned over 25 years ago which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones vitamins fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes leading to the regulation of target genes often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
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